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Novel imaging-based assay for hERG channel inhibition using iPS-derived Cardiomyocytes

Apr 4, 2019

It has been reported that certain drugs prolong the QT interval through a delayed inhibitory effect on the hERG channel by reducing the density of hERG channels on the plasma membrane after chronic drug exposure. In order to develop a highly predicative assay to detect QT prolongation potential after chronic treatment,we used human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM).In the present study, we would like to introduce a novel cardiotoxicity assay method that utilizes live-cell imaging analysis and present the results of several agents, such as cycloheximide, geldanamycine, tunicamycine, desipramine, breferdine and pentmidine, which affect hERG channel synthesis, trafficking and the glycosylation process.

Yokogawa

Yokogawa is a leading provider of confocal quantitative live cell imaging platforms. Combining superior technology with engineering services, project management, and maintenance, Yokogawa delivers field proven operational efficiency, safety, quality, and reliability.

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https://www.yokogawa.com/solutions/products-platforms/life-science/high-content-analysis/cellvoyager-cq1/