High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma

Engineered with superior optics and industry leading technology, Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence, fluorescence and X-ray in vivo imaging. Intelligently designed around the needs of animal scientists, all Spectral Instrument Imaging systems include a robust build, patented LED illumination source, custom filter options, -90°C cooled camera, and absolute calibration.
Bioluminescent signal intensity is a function of luciferase substrate kinetics. These kinetics are generally tissue dependent and can also vary over time, as a result of disease-related pathologies and physiologies. In BLI studies, one should identify and compare peak bioluminescent values over the time course of the study. This is best done by establishing bioluminescent kinetic curves at each imaging time point. Such curves are made by injecting, anesthetizing and then imaging animals over a span of several time points post-luciferin injection. Typically, imaging starts at 5 minutes post injection, is repeated every 5-10 minutes, and completed once signal intensities start to decline.

Read more about Bioluminescence (BLI) and X-Ray in vivo imaging applications in case of lung squamous cell carcinoma (LUSC), in a study published in Nature in February 2021.